| Identification | Back Directory | [Name]
2-Amino-4-(benzyloxy)pyridine | [CAS]
85333-26-2 | [Synonyms]
4-(Benzyloxy)pyridin-2-amine
2-Amino-4-(benzyloxy)pyridine
4-phenylmethoxy-2-pyridinamine
4-phenylmethoxypyridin-2-amine
2-Pyridinamine, 4-(phenylmethoxy)- | [Molecular Formula]
C12H12N2O | [MDL Number]
MFCD12405835 | [MOL File]
85333-26-2.mol | [Molecular Weight]
200.24 |
| Chemical Properties | Back Directory | [Boiling point ]
379.7±27.0 °C(Predicted) | [density ]
1.180 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
7.76±0.11(Predicted) | [Appearance]
Light yellow to yellow Solid | [InChI]
InChI=1S/C12H12N2O/c13-12-8-11(6-7-14-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2,(H2,13,14) | [InChIKey]
RAFCWIXBEWVPGL-UHFFFAOYSA-N | [SMILES]
C1(N)=NC=CC(OCC2=CC=CC=C2)=C1 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P305+P351+P338 |
| Hazard Information | Back Directory | [Synthesis]
Step A: Preparation of 4-(benzyloxy)pyridin-2-amine: 4-(benzyloxy)-2-chloropyridine (1.10 g, 5.01 mmol), Pd2dba3 (46 mg, 0.05 mmol), and 2-(dicyclohexylphosphino)-2',4',6'-tripropyl-1,1 '-biphenyl (57 mg, 0.120 mmol) were dissolved in THF (10 mL) in THF (10 mL) and a 1.0 M solution of ammonia in THF (6 mL) was added. The mixture was heated to 65 °C for 30 min of reaction and then cooled to room temperature. The reaction mixture was concentrated by a silica gel column and eluted with a 20:1 solvent mixture of ethyl acetate/methanol to give a light golden solid product (0.97 g, 96% yield). | [References]
[1] Patent: EP2090575, 2009, A1. Location in patent: Page/Page column 54-55
[2] Patent: WO2018/65365, 2018, A1. Location in patent: Page/Page column 114-115
[3] Patent: WO2007/89512, 2007, A1. Location in patent: Page/Page column 181 |
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