| Identification | Back Directory | [Name]
ECK | [CAS]
853787-75-4 | [Synonyms]
Sek
ECK
Eph
Sek1
Myk2
EPA1
CEK8
HEK8
EPHT
EPHT1
TYRO1
ARCC2
CTPP1
MPK-5
SEK-2
Epha2
Epha4
MGC163163
EPH receptor A2
eph receptor a4
EphA2 active human
Epithelial cell kinase
Ephrin type-A receptor 4
Ephrin type-A receptor 2
Ephrin type-A receptor 2 precursor
Tyrosine-protein kinase receptor EPH
Anti-EPHA1 antibody produced in rabbit
Recombinant Human EPHA2 Protein, Fc Tag
Recombinant Human EPHA4 Protein, Fc Tag
Recombinant Human EPHA4 Protein, His Tag
EPHA4 (610-887), active, GST tagged human
EPHA2 (561-end), active, GST tagged human
EPHA1 (569-end), active, GST tagged human
Anti-EPHA4 (AB1) antibody produced in rabbit
Anti-EPHA4 (AB2) antibody produced in rabbit
EPHA1 (569-end), active, GST tagged from mouse
Monoclonal Anti-EPHA4 antibody produced in mouse
Monoclonal Anti-EPHA1 antibody produced in mouse
ANTI-MOUSE EPHA2 (CENTER) antibody produced in rabbit
ANTI-MOUSE EPHA4 (CENTER) antibody produced in rabbit
Thieno[3,4-b]-1,4-dioxin, 5,5',5''-(1,3,5-benzenetriyl)tris[2,3-dihydro- | [Molecular Formula]
C24H18O6S3 | [MDL Number]
MFCD01867520 | [MOL File]
853787-75-4.mol | [Molecular Weight]
498.59 |
| Chemical Properties | Back Directory | [Boiling point ]
665.1±55.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [storage temp. ]
-70°C | [form ]
buffered aqueous solution | [biological source]
rabbit | [Specific Activity]
74-102nmol/min·mg |
| Hazard Information | Back Directory | [Uses]
EPHA2 (ephrin receptor A2) belongs to the Eph family of receptor tyrosine kinases. It is a type I transmembrane protein, and its exoplasmic domain consists of a ligand binding domain in its N-terminal, a cysteine-rich domain, and two fibronectin type III repeats. Its cytoplasmic domain contains a juxtamembrane region, a tyrosine kinase domain, a SAM (sterile-α-motif) motif, and a PDZ-binding domain. | [Biological Activity]
EPHA2 binds to the ephrin-A ligand and has diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process can be reversed by ligation of EPHA2. |
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