| Chemical Properties | Back Directory | [Boiling point ]
467.3±10.0 °C(Predicted) | [density ]
1.15±0.1 g/cm3(Predicted) | [form ]
solid | [pka]
14.28±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
3-Deoxyaphidicolin exhibits phytotoxic efficacy, that inhibits root growth of lettuce seedlings. 3-Deoxyaphidicolin also exhibits leishmanicidal activity against Leishmania major and Leishmania braziliensis[1][2]. | [Biological Activity]
Inhibitor of eukaryotic DNA synthesis. Mycotoxin. Phytotoxic and cytotoxic agent. Specific inhibitor of DNA polymerase alpha. | [storage]
+4°C | [References]
[1] Haraguchi T, et al., Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate. Nucleic Acids Res. 1983 Feb 25;11(4):1197-209. DOI:10.1093/nar/11.4.1197
[2] Santos G B, et al., The semisynthetic landscape of aphidicolin: inspiration towards leishmanicidal compounds[J]. Journal of the Brazilian Chemical Society, 2014, 25: 1885-1899. |
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Lynnchem
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Novachemistry
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https://www.novachemistry.com/ |
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