| Identification | Back Directory | [Name]
L-Glutamic acid, N-(4-(2-(2-amino-1,4-dihydro-4-oxopyrido(2,3-d)pyrimi din-6-yl)ethyl)bezoyl)- | [CAS]
85597-18-8 | [Synonyms]
10-Dideazafolic acid
5,10-dideazafolic acid
5,10Dideazafolic acid,5,10 Dideazafolic acid
L-Glutamic acid, N-[4-[2-(2-amino-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]-
L-Glutamic acid, N-(4-(2-(2-amino-1,4-dihydro-4-oxopyrido(2,3-d)pyrimi din-6-yl)ethyl)bezoyl)- | [Molecular Formula]
C21H21N5O6 | [MOL File]
85597-18-8.mol | [Molecular Weight]
439.42 |
| Hazard Information | Back Directory | [Uses]
5,10-Dideazafolic acid is a 5,10-dideaza-5,6,7,8-tetrahydrofola analogue, which exhibits some inhibitory activity against glycine amide ribonucleotide formyltransferase (GARFT) (Ki=13 μM)[1]. | [References]
[1] Baldwin, et al. "Structural features of 5, 10-dideaza-5, 6, 7, 8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase." Biochemistry 30.7 (1991): 1997-2006. DOI:10.1021/bi00221a037 |
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