| Identification | Back Directory | [Name]
(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one | [CAS]
856435-40-0 | [Synonyms]
MDM2p53IN1b
MDM2-p53-IN-1b
MDM2 p53 IN 1b
MDM2-p53 inhibitor 1b
(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one | [Molecular Formula]
C17H15NO3 | [MOL File]
856435-40-0.mol | [Molecular Weight]
281.31 |
| Hazard Information | Back Directory | [Description]
MDM2-p53-IN-1b is an inhibitor of the MDM2-p53 interaction. | [Uses]
Antiproliferative agent-62 is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116. | [References]
[1] Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity |
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