| Identification | Back Directory | [Name]
m-PEG3-S-Acetyl | [CAS]
857284-78-7 | [Synonyms]
m-PEG3-S-Acetyl
Methyl-PEG3-S-acetyl
Ethanethioic acid, S-[2-[2-(2-methoxyethoxy)ethoxy]ethyl] ester | [Molecular Formula]
C9H18O4S | [MDL Number]
MFCD22574766 | [MOL File]
857284-78-7.mol | [Molecular Weight]
222.3 |
| Hazard Information | Back Directory | [Description]
m-PEG3-S-Acetyl is a PEG linker with a sulfur-acetyl end group. The sulfur acetyl group can be deprotected to generate thiol groups. After the formation of the thiol group, it is able to react with maleimides, disulfides, haloacteamides and other thiols. The hydrophilic PEG linker increases the solubility of the compound in aqueous media. | [Uses]
m-PEG3-S-Acetyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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