| Identification | Back Directory | [Name]
Ambamustine | [CAS]
85754-59-2 | [Synonyms]
Ambamustine
Unii-ib1H345F24
Ambamustine [inn]
Ambamustine USP/EP/BP
L-Methionine, 4-fluoro-L-phenylalanyl-3-[bis(2-chloroethyl)amino]-L-phenylalanyl-, ethyl ester
N-(3-(m-(Bis(2-chloroethyl)amino)phenyl)-N-(3-(p-fluorophenyl)-L-alanyl)-L-alanyl)-L-methionine, ethyl ester | [Molecular Formula]
C29H39Cl2FN4O4S | [MDL Number]
MFCD00866279 | [MOL File]
85754-59-2.mol | [Molecular Weight]
629.621 |
| Hazard Information | Back Directory | [Uses]
Ambamustine (PTT119) is a new bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities[1][2]. | [References]
[1] M J Yagi, et al. Interference of mouse mammary tumor virus replication by PTT.119 [p-fluoro-L-phe-m-bis-(2-chloroethyl)amino-L-phe-met ethoxy HCl]--an antitumor agent. J Natl Cancer Inst. 1986 Mar;76(3):493-501. PMID:3005743
[2] A Ardizzoni, et al. Ambamustine in the second-line treatment of patients with small-cell lung cancer: a phase II Fonicap study. Am J Clin Oncol. 2000 Feb;23(1):22-5. DOI:10.1097/00000421-200002000-00005 |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|