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857629-79-9

857629-79-9 Structure

857629-79-9 Structure
IdentificationBack Directory
[Name]

(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
[CAS]

857629-79-9
[Synonyms]

Entacapone impurity D
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-
Entacapone Impurity 4(Entacapone EP Impurity D)
Entacapone Impurity 4(Entacapone EP Impurity A)
Entacapone Impurity 20(Entacapone EP Impurity D)
(E)-N,N-diethyl-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)acrylamide
(E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylacrylamide
(E)-2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
2-Propenamide, 2-cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
Imp. D (EP):(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
[Molecular Formula]

C16H19N3O5
[MOL File]

857629-79-9.mol
[Molecular Weight]

333.34
Hazard InformationBack Directory
[Uses]

(2E)-2-Cyano-3-(3-ethoxy-4-hydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide is an impurity of Entacapone (E558500), a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
[Definition]

ChEBI:3-O-ethylentacapone is a C-nitro compound that is entacapone in which the phenolic hydroxy group that is meta to the nitro group has been converted into the corresponding ethyl ether. It is a monocarboxylic acid amide, a nitrile, an aromatic ether and a member of 2-nitrophenols. It is functionally related to a 5-nitrovanillin and an entacapone.
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