| Identification | Back Directory | [Name]
DNP-PEG4-acid | [CAS]
858126-76-8 | [Synonyms]
DNP-PEG4-acid
DNP-PEG4-COOH
DNP-PEG5-acid
DNP-dPEG??-acid
1-(2,4-Dinitrophenylamino)-3,6,9,12-tetraoxapentadecanoic acid
Propanoic acid, 3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]- | [Molecular Formula]
C17H25N3O10 | [MDL Number]
MFCD13184986 | [MOL File]
858126-76-8.mol | [Molecular Weight]
431.39 |
| Hazard Information | Back Directory | [Description]
DNP-PEG4-acid is a PEG linker containing a DNP and carboxylic acid moiety. DNP is involved in biological applications such as participating in ion transport across membranes. The terminal carboxylic acid can react with primary amines in the presence of EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. | [Uses]
DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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