| Identification | Back Directory | [Name]
AR 244555 | [CAS]
858350-62-6 | [Synonyms]
AR 244555
Methanone, [1'-(3-buten-1-yl)-5-chloro-1,2-dihydrospiro[3H-indole-3,4'-piperidin]-1-yl](2,6-difluorophenyl)- | [Molecular Formula]
C23H23ClF2N2O | [MDL Number]
MFCD28138741 | [MOL File]
858350-62-6.mol | [Molecular Weight]
416.89 |
| Hazard Information | Back Directory | [Uses]
AR244555 is a malate-aspartate shuttle (MAS) inverse agonist with IC50s of 186 nM and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively. AR244555 has cardioprotective effects[1]. | [References]
[1] Tong Zhang, et al. Inhibition of Mas G-protein signaling improves coronary blood flow, reduces myocardial infarct size, and provides long-term cardioprotection. Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H299-311. DOI:10.1152/ajpheart.00723.2011 |
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BOC Sciences
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https://www.bocsci.com |
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