| Identification | Back Directory | [Name]
4-IODO-2-PYRIDONE | [CAS]
858839-90-4 | [Synonyms]
4-IODO-2-PYRIDONE
4-Iodo-2-pyridinone
4-Iodopyridin-2(1H)
4-Iodo-2(1H)-pyridinone
4-Iodo-2-hydroxypyridine
4-iodo-2-pyridone , 97+%
2-Hydroxy-4-iodopyridine
4-iodo-1,2-dihydropyridin-2-one | [EINECS(EC#)]
690-950-8 | [Molecular Formula]
C5H4INO | [MDL Number]
MFCD09702419 | [MOL File]
858839-90-4.mol | [Molecular Weight]
221 |
| Chemical Properties | Back Directory | [Melting point ]
186-188°C | [Boiling point ]
321.6±35.0 °C(Predicted) | [density ]
2.12±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
10.76±0.10(Predicted) | [color ]
Pale brown | [CAS DataBase Reference]
858839-90-4 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL METHOD: 2-chloro-4-iodopyridine (prepared above) was heated with sodium acetate (2.0 eq.) in 1.0 M acetic acid solution at 150°C for 72 hours in a sealed tube. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was partitioned between ethyl acetate (3 mL/mmol) and cold water (3 mL/mmol). The aqueous layer was extracted with ethyl acetate (3 mL/mmol; 4 times). The combined organic layers were washed sequentially with saturated NaHCO3 solution (1 mL/mmol), brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel fast column chromatography to afford 4-iodo-2-pyridinone (1b/c/d), details of the specific compound are given below. | [References]
[1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Patent: US2010/331320, 2010, A1. Location in patent: Page/Page column 89; 90
[3] Patent: WO2015/101928, 2015, A1. Location in patent: Page/Page column 48
[4] Patent: WO2012/32014, 2012, A1. Location in patent: Page/Page column 94
[5] Patent: US2012/214782, 2012, A1. Location in patent: Page/Page column 40 |
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