| Identification | Back Directory | [Name]
6-IODONORDIHYDROCAPSAICIN | [CAS]
859171-97-4 | [Synonyms]
6'-Iodononivamide
6-IODONORDIHYDROCAPSAICIN
6-IODONORDIHYDROCAPSAICIN USP/EP/BP | [Molecular Formula]
C17H26INO3 | [MDL Number]
MFCD09878233 | [MOL File]
859171-97-4.mol | [Molecular Weight]
419.3 |
| Hazard Information | Back Directory | [Uses]
6-?iodonordihydrocapsaicin (6-?I-?CPS) is a weak ERα agonist. It was demonstrated to induce luciferase gene expression. | [Definition]
ChEBI: N-[(4-hydroxy-2-iodo-5-methoxyphenyl)methyl]nonanamide is a member of phenols and a member of methoxybenzenes. | [Biological Activity]
the vanilloid trpv1 receptor, also known as vr1 receptor, belongs to the large family of ‘transient receptor potential’ (trp). trpv1 functions as a molecular integrator of nociceptive stimuli, including heat, protons and plant toxins, and is most abundant in peripheral sensory fibers of the c and ad type. 6-iodo-nordihydrocapsaicin is a potent trpv1 antagonist. | [in vitro]
using human recombinant trpv1, 6-iodonordihydrocapsaicin (ic50=10 nm against 100 nm capsaicin) was about four times more potent than the prototypical trpv1 antagonist, capsazepine [1]. | [in vivo]
6-iodonordihydrocapsaicin was tested against capsaicin also on native trpv1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. in all cases, except for the guineapig bronchi, the compound was significantly more potent than capsazepine as a trpv1 antagonist [1]. | [IC 50]
10 nm against 100 nm capsaicin | [References]
[1] appendino g, harrison s, de petrocellis l, daddario n, bianchi f, schiano moriello a, trevisani m, benvenuti f, geppetti p, di marzo v. halogenation of a capsaicin analogue leads to novel vanilloid trpv1 receptor antagonists. br j pharmacol. 2003 aug;139(8):1417-24. |
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