| Identification | Back Directory | [Name]
Piperazine, 1-(cyclopropylmethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]- | [CAS]
859217-52-0 | [Synonyms]
E6007
Milategrast
Piperazine, 1-(cyclopropylmethyl)-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]- | [Molecular Formula]
C24H38N2 | [MOL File]
859217-52-0.mol | [Molecular Weight]
354.57 |
| Chemical Properties | Back Directory | [Boiling point ]
441.4±45.0 °C(Predicted) | [density ]
0.991±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
8.67±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Milategrast is useful as cell adhesion inhibitor or cell infiltration inhibitor. Milategrast in vitro inhibites the adhesion of Jurkat cells to human fibronectin with an IC50 of ＜5 μM[1]. | [References]
[1] Huang H, et al. Microplastics in the bloodstream can induce cerebral thrombosis by causing cell obstruction and lead to neurobehavioral abnormalities. Sci Adv. 2025 Jan 24;11(4):eadr8243. DOI:10.1126/sciadv.adr8243
[2] Kotake, et al.Preparation of various crystal forms and salts of 1-cyclopropylmethyl-4-[2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine for treating or preventing various inflammatory diseases and autoimmune diseases.WO2006068058A1 |
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