| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]- | [CAS]
859518-94-8 | [Synonyms]
T0467
2-Pyrimidinamine, N-[2-(3,5-difluorophenyl)ethyl]-4-[2-fluoro-5-[[(2S)-2-methyl-1-piperazinyl]methyl]phenyl]-
N-[2-(3,5-difluorophenyl)ethyl]-4-(2-fluoro-5-{[(2S)-
2-methylpiperazin-1-yl]methyl}phenyl)pyrimidin-2-
amine | [Molecular Formula]
C24H26F3N5 | [MOL File]
859518-94-8.mol | [Molecular Weight]
441.49 |
| Chemical Properties | Back Directory | [Boiling point ]
570.2±60.0 °C(Predicted) | [density ]
1.251±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 33.33 mg/mL (75.49 mM; Need ultrasonic) | [form ]
Solid | [pka]
9.14±0.40(Predicted) | [color ]
Off-white to light brown |
| Hazard Information | Back Directory | [Uses]
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1]. | [Biological Activity]
T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson’s disease and related disorders research[1].
T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1].T0467 does not show obvious toxicity in Drosophila at concentrations Drosophila larval muscles[1]. | [References]
[1]. Kahori Shiba-Fukushima, et al. A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling. iScience. 2020 May 22;23(5):101048. |
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