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86-08-8

86-08-8 Structure

86-08-8 Structure
IdentificationBack Directory
[Name]

3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE
[CAS]

86-08-8
[Synonyms]

APAD
3-ACETYLPYRIDINE NAD
acetyldiphosphopyridine nucleotide
3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE
3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE, REDUCED FORM
3-Acetylpyridine hypoxanthine dinucleotide,oxidized form
3-Acetylpyridine adenine dinucleotide, oxidised form 92+%
5'-ester with 3-acetyl-1-b-D-ribofuranosylpyridinium, inner salt
3-Acetyl-1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyridin-1-ium
[EINECS(EC#)]

201-649-4
[Molecular Formula]

C22H28N6O14P2
[MDL Number]

MFCD00078882
[MOL File]

86-08-8.mol
[Molecular Weight]

662.44
Chemical PropertiesBack Directory
[storage temp. ]

−20°C
[solubility ]

PBS (pH 7.2): 10 mg/ml
[form ]

A crystalline solid
[color ]

White to light yellow
[biological source]

Porcine brain
[Water Solubility ]

water: 50mg/mL, clear, colorless to faintly yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P271-P261-P280
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
[HS Code ]

2934999090
Hazard InformationBack Directory
[Description]

3-Acetylpyridine NAD (APAD) is an analog of NAD+ (free acid) (nicotinamide adenine dinucleotide; ), a signaling molecule and cofactor or substrate for many enzymes. APAD has been used to study the mechanisms of oxidative phosphorylation. It can be reduced by transdehydrogenase from NADH (sodium salt) . It can be reduced more efficiently and is more stable than NAD+; thus, it is useful as a substitute.
[Uses]

3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite[1][2].
[Definition]

ChEBI: 3-acetylpyridine adenine dinucleotide is an organic molecular entity.
[References]

[1] Boland MJ. NADH-dependent glutamate synthase from lupin nodules. Reactions with oxidised and reduced 3-acetylpyridine-adenine dinucleotide. Eur J Biochem. 1981 Apr;115(3):485-9. PMID:7238515
[2] Ciaccio EI. The inhibition of lactate dehydrogenase by 3-acetylpyridine adenine dinucleotide and bisulfite. J Biol Chem. 1966 Apr 10;241(7):1581-6. PMID:5946616
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