| Identification | Back Directory | [Name]
Quazolast | [CAS]
86048-40-0 | [Synonyms]
RHC3988
RHC-3988
RHC 3988
Quazolast
methyl 5-chlorooxazolo[4,5-h]quinoline-2-carboxylate
5-Chlorooxazolo[4,5-h]quinoline-2-carboxylic acid methyl ester
Oxazolo[4,5-h]quinoline-2-carboxylic acid, 5-chloro-, methyl ester | [Molecular Formula]
C12H7ClN2O3 | [MDL Number]
MFCD00864797 | [MOL File]
86048-40-0.mol | [Molecular Weight]
262.65 |
| Hazard Information | Back Directory | [Uses]
Anti-asthmatic; inhibitor (mediator release). | [Definition]
ChEBI: Quazolast is a member of quinolines and an organochlorine compound. | [in vivo]
Quazolast (0.2, 1, 5 mg/kg; p.o.) reduces the gastric damage in rats induced by absolute ethanol (0.9 mg/kg)[1].
Quazolast (3.1, 6.3, 12.5, 25 mg/kg; p.o.) reduces the gastric damage associated with 0.6 N HC1 administration[1]. | Animal Model: | 150 g Male Sprague Dawley rat[1] | | Dosage: | 0.2, 1, 5 mg/kg | | Administration: | P.o. | | Result: | Decreased the rat gastric mucosa damage in a dose dependent manner and reduced the gastric ulcer index (68%) at 5 mg/kg in rat induced by absolute ethanol (0.9 mg/kg). |
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