| Identification | Back Directory | [Name]
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL | [CAS]
86215-36-3 | [Synonyms]
CL216303
CL-216303
CL 216303
CL-216303 HCl
DOV216303 HCl
CL216303 HCl,CL 216303 HCl
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride
1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride | [Molecular Formula]
C11H12Cl3N | [MDL Number]
MFCD06407666 | [MOL File]
86215-36-3.mol | [Molecular Weight]
264.58 |
| Chemical Properties | Back Directory | [storage temp. ]
?20°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
powder | [color ]
white to beige | [InChI]
1S/C11H11Cl2N.ClH/c12-9-2-1-7(3-10(9)13)11-4-8(11)5-14-6-11;/h1-3,8,14H,4-6H2;1H | [InChIKey]
KAGBHVBIOJBGBD-UHFFFAOYSA-N | [SMILES]
Cl.Clc1ccc(cc1Cl)C23CNCC2C3 | [CAS DataBase Reference]
86215-36-3 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H319 | [Precautionary statements ]
P301+P310+P330-P305+P351+P338 | [Hazard Codes ]
T | [Risk Statements ]
25-36 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HS Code ]
2933990099 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3]. | [Biological Activity]
Triple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~2014and 78 nMrespectively. | [References]
[1] Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. DOI:10.1111/j.1527-3458.2006.00123.x
[2] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[3] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561 |
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