| Identification | Back Directory | [Name]
Acetamide, N-[4-[[6-[4-[(1S)-1-(4-fluorophenyl)ethyl]-1-piperazinyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]- | [CAS]
862269-92-9 | [Synonyms]
AMG-628, (S)-
Acetamide, N-[4-[[6-[4-[(1S)-1-(4-fluorophenyl)ethyl]-1-piperazinyl]-4-pyrimidinyl]oxy]-2-benzothiazolyl]- | [Molecular Formula]
C25H25FN6O2S | [MOL File]
862269-92-9.mol | [Molecular Weight]
492.57 |
| Hazard Information | Back Directory | [Uses]
(S)-AMG-628 (Compound 16q) is the S-isomer of AMG-628 (HY-123374). (S)-AMG-628 is the orally active antagonist for TRPV1, that inhibits the Capsaicin (HY-10448)- and acid-induced Ca2+-influx with IC50 of 7 nM and 5 nM in CHO cell. (S)-AMG-628 ameliorates Capsaicin-induced rats flinching, and reverses the thermal hypersensitivity in CFA-(HY-153808) induced inflammatory pain models[1]. | [References]
[1] Wang HL, et al., Novel vanilloid receptor-1 antagonists: 3. The identification of a second-generation clinical candidate with improved physicochemical and pharmacokinetic properties. J Med Chem. 2007 Jul 26;50(15):3528-39. DOI:10.1021/jm070191h |
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