| Identification | Back Directory | [Name]
L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[2,3-dihydro-2-(2-hydroxyethyl)-5-methoxy-3-oxo-4-pyridazinyl]- | [CAS]
863226-74-8 | [Synonyms]
L-Phenylalanine, N-(2,6-dichlorobenzoyl)-4-[2,3-dihydro-2-(2-hydroxyethyl)-5-methoxy-3-oxo-4-pyridazinyl]- | [Molecular Formula]
C23H21Cl2N3O6 | [MOL File]
863226-74-8.mol | [Molecular Weight]
506.34 |
| Hazard Information | Back Directory | [Uses]
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α4integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between α4β1/VCAM-1 and α4β7/MAdCAM-1, with IC50 values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model[1]. | [IC 50]
α4β1; α4β7 | [References]
[1] Gong Y, et al. Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists. J Med Chem. 2006 Jun 1;49(11):3402-11. DOI:10.1021/jm060031q |
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