| Identification | Back Directory | [Name]
3-Methylseleno-L-alanine Hydrochloride | [CAS]
863394-07-4 | [Synonyms]
3-(Methylseleno)-Ala-OH.HCl
Se-Methylselenocysteine HCL
3-Methylseleno-L-alanine Hydrochloride
Se-(Methyl)selenocysteine hydrochloride >=95% (TLC)
(R)-2-aMino-3-(Methylselanyl)propanoic acid hydrochloride | [Molecular Formula]
C4H10ClNO2Se | [MDL Number]
MFCD03412450 | [MOL File]
863394-07-4.mol | [Molecular Weight]
218.541 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMF: 1 mg/ml,DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [InChI]
1S/C4H9NO2Se.ClH/c1-8-2-3(5)4(6)7;/h3H,2,5H2,1H3,(H,6,7);1H/t3-;/m0./s1 | [InChIKey]
JMPVTFHGWJDSDV-DFWYDOINSA-N | [SMILES]
Cl.C[Se]C[C@H](N)C(O)=O |
| Hazard Information | Back Directory | [Uses]
Se-(Methyl) selenocysteine hydrochloride has been used as a standard in fluorescence-XANES (X-ray absorption near-edge spectroscopy) imaging. | [General Description]
Selenium (Se)-(Methyl) selenocysteine (MeSeCys) is a methylated product of selenocysteine, this reaction is catalyzed by selenocysteine methyltransferase (SMT) in Astragalus bisulcatus. | [Biochem/physiol Actions]
Selenium (Se)-(Methyl) selenocysteine functions as a potent chemotherapeutic agent for human breast cancer. Enhanced production of methlylselenol from L-Se-methylselenocysteine in vivo alters redox status of cells and oxidatively triggers cellular apoptosis. It is implicated in inhibition of mammary tumor formation in rats. | [in vivo]
Se-Methylselenocysteine hydrochloride (0.2?mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].
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Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine hydrochloride (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine hydrochloride reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine hydrochloride modulates the distribution and levels of several metal ions; Se-Methylselenocysteine hydrochloride decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3]. |
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