| Chemical Properties | Back Directory | [Boiling point ]
551.4±40.0 °C(predicted) | [density ]
1.245±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
7.30±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
HSD17B13-IN-7 (compound 1), a fluorophenol-containing compound, is a potent HSD17B13 inhibitor with IC50s of 0.18 μM and 0.25 μM β-estradiol and Leukotriene B4 as substrates, respectively. HSD17B13-IN-7 is a potent N-methyl-D-aspartate (NMDA) NR2B receptor antagonist. HSD17B13-IN-7 has the potential for non-alcoholic fatty liver disease research[1]. | [IC 50]
NR2B | [References]
[1] Shenping Liu, et al. Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun. 2023 Aug 24;14(1):5158. DOI:10.1038/s41467-023-40766-0 |
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