| Identification | Back Directory | [Name]
2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol | [CAS]
86361-55-9 | [Synonyms]
Gnetol
Gnetol>
-2-(3,5-Dihydroxystyryl)
2,3',5',6-Tetrahydroxy-trans-stilbene
(E)-2-(3,5-Dihydroxystyryl)benzene-1,3-diol
2-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol
1,3-Benzenediol, 2-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-
2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol USP/EP/BP | [EINECS(EC#)]
617-839-9 | [Molecular Formula]
C14H12O4 | [MDL Number]
MFCD12405548 | [MOL File]
86361-55-9.mol | [Molecular Weight]
244.243 |
| Chemical Properties | Back Directory | [Melting point ]
271°C(lit.) | [Boiling point ]
540.8±30.0 °C(Predicted) | [density ]
1.468±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder to crystal | [pka]
9.06±0.40(Predicted) | [color ]
White to Light yellow to Light orange | [λmax]
337nm(EtOH)(lit.) | [CAS DataBase Reference]
86361-55-9 |
| Hazard Information | Back Directory | [Uses]
Gnetol (cas# 86361-55-9) is a compound useful in organic synthesis. | [in vivo]
Male Sprague-Dawley rats were cannulated and dosed either intravenously with Gnetol (10?μg/kg) or orally (100?mg/kg). After oral and intravenous administration, Gnetol is detected in both serum and urine as the parent compound and as a glucuronidated metabolite. The bioavailability of Gnetol is determined to be 6%. Gnetol is rapidly glucuronidated and is excreted in urine and via nonrenal routes[1].
Pretreatment of Male NIH Swiss mice (20-35 g) with Gnetol (50mg/kg, SC) is able to increase the latency period to response in analgesia models[1]. | [target]
Tyrosinase | BACE | [IC 50]
COX-1: 0.78 μM (IC50); Tyrosinase: 4.5 μM (IC50); HDAC |
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