| Identification | Back Directory | [Name]
Methoxy-X04 | [CAS]
863918-78-9 | [Synonyms]
Methoxy-X04
4,4'-[(2-methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol | [Molecular Formula]
C23H20O3 | [MDL Number]
MFCD25563254 | [MOL File]
863918-78-9.mol | [Molecular Weight]
344.403 |
| Chemical Properties | Back Directory | [Boiling point ]
554.2±29.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C,protect from light | [solubility ]
Soluble in DMSO | [form ]
crystalline solid | [pka]
9.98±0.26(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer''s disease. For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging. Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm. | [Uses]
Methoxy-X04 is a small molecule Aβ-binding agent, which exhibits anti-amyloid effects. | [in vivo]
Methoxy-X04 (5-10 mg/kg, i.p., once time) differentiates individual plaques in PS1/APP mice within 30 to 60 min[2].
| [storage]
+4°C. Protect from light. | [References]
[1] WILLIAM E KLUNK. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.[J]. Journal of Neuropathology and Experimental Neurology, 2002, 61 9: 797-805. DOI: 10.1093/jnen/61.9.797
[2] STEFFEN BURGOLD. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks[J]. Acta Neuropathologica, 2010, 121 3: 327-335. DOI: 10.1007/s00401-010-0787-6 |
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Lynnchem
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86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
Novachemistry
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44-20819178-90 02081917890 |
| Website: |
https://www.novachemistry.com/ |
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