| Identification | Back Directory | [Name]
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid | [CAS]
863971-44-2 | [Synonyms]
FMOC-3AA-OH
Fmoc-3vvd-OH
Fmoc-3AA-orl
Tripeptide (MMAE-3)
Fmoc-Meval-val-dolaisoleucine-OH
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L-
valinamide
L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-
(5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid | [Molecular Formula]
C36H51N3O7 | [MDL Number]
MFCD28386982 | [MOL File]
863971-44-2.mol | [Molecular Weight]
637.81 |
| Chemical Properties | Back Directory | [Boiling point ]
793.0±60.0 °C(Predicted) | [density ]
1.144±0.06 g/cm3(Predicted) | [solubility ]
DMSO: ≥ 37 mg/mL (58.01 mM) | [form ]
Solid | [pka]
4.08±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) | [InChIKey]
JDMOCVJBADMSJP-FCUBIXSHSA-N | [SMILES]
C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C |
| Hazard Information | Back Directory | [Uses]
Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis. | [Biological Activity]
Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. | [in vivo]
ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers. | [target]
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