| Identification | Back Directory | [Name]
Denatonium Benzoate Monohydrate | [CAS]
86398-53-0 | [Synonyms]
DenatoniuM Benzoate Hydrate
Denatonium Benzoate (200 mg)
Denatonium benzoate [usan:inn:ban]
DENATONIUM BENZOATE (200 MG)I1F0251.000MG/MG(DR)
Benzenemethanaminium, N-(2-((2,6-dimethylphenyl)amino)-2-oxoethyl)-N,N-diethyl-, benzoate, monohydrate | [Molecular Formula]
C28H36N2O4 | [MOL File]
86398-53-0.mol | [Molecular Weight]
464.596 |
| Chemical Properties | Back Directory | [solubility ]
Very soluble in chloroform, and methanol; soluble in ethanol (95%), and water; sparingly soluble in acetone; practically insoluble in ether. |
| Hazard Information | Back Directory | [Chemical Properties]
Denatonium benzoate occurs as an odorless, very bitter tasting, white crystalline powder or granules. | [Uses]
Denatonium Benzoate Hydrate is a stimulant of the bitter taste receptors which allows for maintenance of the airways. Bronchodilator. | [Uses]
Pharmaceutic aid (alcohol denaturant); pharmaceutic aid (flavor). | [Production Methods]
Denatonium benzoate was first synthesized in the 1950s and is usually prepared by reacting denatonium chloride with benzyl benzoate. | [Brand name]
Bitrex (Mac Farlan Smith, Scotland). | [Pharmaceutical Applications]
Denatonium benzoate is among the most bitter of substances
known and is detectable at concentrations of approximately 10 ppb.
In pharmaceutical and other industrial applications it is added to
some products as a deterrent to accidental ingestion. It is most
commonly used at levels of 5–500 ppm. Denatonium benzoate may
also be used to replace brucine or quassin as a denaturant for
ethanol.
In pharmaceutical formulations, denatonium benzoate has been
used as a flavoring agent in placebo tablets, and in a topical
formulation it has been used in an anti-nailbiting preparation. | [Safety]
Denatonium benzoate is generally regarded as a nonirritant and nonmutagenic substance.However,there has been a single report of contact urticaria attributed to denatonium benzoate occurring in a 30-year-old man who developed asthma and pruritus after using an insecticidal spray denatured with denatonium benzoate.
LD50 (rabbit, oral): 0.508g/kg
LD50 (rat, oral): 0.584g/kg
| [storage]
Denatonium benzoate is stable up to 140°C and over a wide pH range. It should be stored in a well-closed container (such as polythene-lined steel) in a cool, dry place. Aqueous or alcoholic solutions retaintheir bitterness forseveral years evenwhenexposed to light. | [Incompatibilities]
Denatonium benzoateis incompatible with strongoxidizing agents. | [Regulatory Status]
Denatonium benzoate is used worldwide as a denaturant for alcohol. It is included in the FDA Inactive Ingredients Database (topical gel and solution). |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Whyte Chemicals
|
| Tel: |
+44 (20) 8346-5946 |
| Website: |
www.whytechemicals.co.uk |
|