| Identification | Back Directory | [Name]
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE | [CAS]
86408-36-8 | [Synonyms]
PMBN
sPMBN
2-10-Polymyxin B1
polymyxinbnonapeptide
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-Thr-)
Nα-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-)
N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-) | [Molecular Formula]
C43H74N14O11 | [MDL Number]
MFCD00214217 | [MOL File]
86408-36-8.mol | [Molecular Weight]
963.13 |
| Chemical Properties | Back Directory | [Boiling point ]
1456.2±65.0 °C(predicted) | [density ]
1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [storage temp. ]
2-8°C
| [solubility ]
Water: ≥ 100 mg/mL (103.83 mM); DMSO: 16.67 mg/mL (17.31 mM) | [form ]
Solid | [pka]
12.10±0.45(predicted) | [color ]
White to off-white | [Sequence]
H-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr10) |
| Hazard Information | Back Directory | [Uses]
Polymyxin B Nonapeptide can be used in biological study of role of outer membrane and porins in susceptibility of β-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam. | [in vivo]
Polymyxin B nonapeptide (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].
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