864293-44-7

3177-80-8

864293-44-7

General procedure for the synthesis of 2-amino-5-bromo-3-methoxybenzoic acid from 2-amino-3-methoxybenzoic acid: 2-amino-3-methoxybenzoic acid (10.0 g, 59.8 mmol, 1.0 eq.) was dissolved in dichloromethane (DCM, 150 mL), followed by addition of N-bromosuccinimide (NBS, 10.6 g, 59.8 mmol 1.0 eq.). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solid product was collected by filtration and washed with dichloromethane (100 mL x 2) to give the final 2-amino-5-bromo-3-methoxybenzoic acid as a gray solid (12.1 g, 82.2% yield).