| Identification | Back Directory | [Name]
2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID | [CAS]
864293-44-7 | [Synonyms]
2-AMino-5-broMo-3-Methoxybenzoic 2-AMINO-5-BROMO-3-METHOXYBENZOIC ACID Benzoic acid, 2-amino-5-bromo-3-methoxy- 2-Amino-5-bromo-3-(methyloxy)benzoic acid | [Molecular Formula]
C8H8BrNO3 | [MDL Number]
MFCD11101005 | [MOL File]
864293-44-7.mol | [Molecular Weight]
246.06 |
| Chemical Properties | Back Directory | [Boiling point ]
356.0±42.0 °C(Predicted) | [density ]
1.703±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [pka]
4.43±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [InChI]
InChI=1S/C8H8BrNO3/c1-13-6-3-4(9)2-5(7(6)10)8(11)12/h2-3H,10H2,1H3,(H,11,12) | [InChIKey]
YSBGYQUUOKRQAT-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC(Br)=CC(OC)=C1N |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-amino-5-bromo-3-methoxybenzoic acid from 2-amino-3-methoxybenzoic acid: 2-amino-3-methoxybenzoic acid (10.0 g, 59.8 mmol, 1.0 eq.) was dissolved in dichloromethane (DCM, 150 mL), followed by addition of N-bromosuccinimide (NBS, 10.6 g, 59.8 mmol 1.0 eq.). The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solid product was collected by filtration and washed with dichloromethane (100 mL x 2) to give the final 2-amino-5-bromo-3-methoxybenzoic acid as a gray solid (12.1 g, 82.2% yield). | [References]
[1] Patent: US2009/203657, 2009, A1. Location in patent: Page/Page column 50 [2] Patent: US2009/203677, 2009, A1. Location in patent: Page/Page column 53 [3] Patent: US2009/197871, 2009, A1. Location in patent: Page/Page column 52-53 [4] Patent: WO2009/100169, 2009, A1. Location in patent: Page/Page column 131 [5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 6087 - 6109 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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