| Identification | Back Directory | [Name]
TC-MCH 7c | [CAS]
864756-35-4 | [Synonyms]
TC-MCH 7c
4-(4-Fluoro-benzyloxy)-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1H-pyridin-2-one
4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone | [Molecular Formula]
C24H25FN2O3 | [MOL File]
864756-35-4.mol | [Molecular Weight]
408.47 |
| Chemical Properties | Back Directory | [Melting point ]
124-126 °C | [Boiling point ]
606.3±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO | [form ]
Powder | [pka]
9.60±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TC-MCH 7c is a potent melanin-concentrating hormone 1 receptor antagonist. | [in vivo]
TC-MCH 7c (oral; 3-30 mg/kg; once-daily for 1.5 months) exhibits excellent body weight reduction in a dose-dependent manner in DIO mice model[1].
TC-MCH 7c (oral; 3-30 mg/kg) with 30 mg/kg has plasma concentrations of 5.1, 1.8, and 0.7 μM at 2, 15, and 24 hours, respectively[2].
| Animal Model: | C57BL/6J DIO mice[1] | | Dosage: | 3, 10 and 30 mg/kg | | Administration: | Oral; once-daily for 1.5 months | | Result: | Exhibited excellent body weight reduction in a dose-dependent manner.
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| Animal Model: | Diet-induced obesity mice[2] | | Dosage: | 3, 10 and 30 mg/kg (Pharmacokinetic Analysis) | | Administration: | Oral | | Result: | Plasma concentrations at 2, 15, and 24 hours were 5.1, 1.8, and 0.7 μM, respectively.
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| [storage]
Store at RT |
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| Company Name: |
BOC Sciences
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| Tel: |
|
| Website: |
https://www.bocsci.com |
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