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864941-31-1

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864941-31-1 Structure

864941-31-1 Structure
IdentificationBack Directory
[Name]

ethyl (2-(5-nitrothiophene-2-carboxamido)thiophene-3-carbonyl)carbamate
[CAS]

864941-31-1
[Synonyms]

EACC
ethyl (2-(5-nitrothiophene-2-carboxamido)thiophene-3-carbonyl)carbamate
Carbamic acid, [[2-[[(5-nitro-2-thienyl)carbonyl]amino]-3-thienyl]carbonyl]-, ethyl ester (9CI)
[Molecular Formula]

C13H11N3O6S2
[MOL File]

864941-31-1.mol
[Molecular Weight]

369.37
Chemical PropertiesBack Directory
[density ]

1.565±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 16.88 mg/mL (45.70 mM)
[form ]

Solid
[pka]

10.36±0.46(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

EACC is a reversible autophagy inhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion[1].
[storage]

Store at -20°C
[References]

[1] Vats S, et al. A reversible autophagy inhibitor blocks autophagosome-lysosome fusion by preventing Stx17 loading onto autophagosomes. Mol Biol Cell. 2019 Aug 1;30(17):2283-2295. DOI:10.1091/mbc.E18-08-0482
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