| Identification | Back Directory | [Name]
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine | [CAS]
865362-74-9 | [Synonyms]
CS-1137
FR 180204
LM-3319
FR 180204
ERK Inhibitor II, FR180204
FR 180204;FR-180204;FR180204
ERK Inhibitor II, FR180204 - CAS 865362-74-9 - Calbiochem
FR 180204, 98%, a potent and selective ATP-competitive inhibitor of ERK
5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine
1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine USP/EP/BP
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine FR 180204 | [Molecular Formula]
C18H13N7 | [MDL Number]
MFCD14585805 | [MOL File]
865362-74-9.mol | [Molecular Weight]
327 |
| Chemical Properties | Back Directory | [Melting point ]
267 °C | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: ≥10mg/mL | [form ]
Yellow solid | [pka]
7.19±0.50(Predicted) | [color ]
faint yellow to dark yellow | [InChI]
1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23) | [InChIKey]
XVECMUKVOMUNLE-UHFFFAOYSA-N | [SMILES]
Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5 |
| Hazard Information | Back Directory | [Uses]
FR180204 has been used as ERK inhibitor:
- to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
- of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
- to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy
| [Definition]
ChEBI: 5-(2-phenyl-3-pyrazolo[1,5-a]pyridinyl)-2H-pyrazolo[3,4-c]pyridazin-3-amine is a member of pyrazoles and a ring assembly. | [Biochem/physiol Actions]
FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2). | [in vivo]
FR180204 (100 mg/kg, i.p., b.i.d.) significantly decreases the severity of symptoms and body weight loss in collagen-induced arthritis mice[2].?In a mouse model of dengue virus (DENV) infection, FR180204 limits hepatocyte apoptosis, reduces DENV-induced liver injury, and improves clinical parameters[4]. | [IC 50]
ERK2: 0.14 μM (Ki); ERK1: 0.31 μM (Ki); ERK2: 0.33 μM (IC50); ERK1: 0.51 μM (IC50) | [storage]
Store at +4°C |
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| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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