ChemicalBook--->CAS DataBase List--->865759-25-7

865759-25-7

865759-25-7 Structure

865759-25-7 Structure
IdentificationBack Directory
[Name]

Trelagliptin
[CAS]

865759-25-7
[Synonyms]

YR-472
CS-926
Zafatek)
Trilagliptin
Trelagliplin
Trelagliptin
Glass acid trigram
Trelagliptin, >=98%
SYR472 Trelagliptin
Trelagliptin(syr472)
Trelagliptin free base
Trelagliptin impurity G
Trelagliptin Impurity 83
SYR-472; SYR472; SYR 472
Trelagliptin Isomer Impurity
TRELAGLIPTIN CAS 865759-25-7
Trelagliptin/Trelagliptin succinate
(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2
4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)
1-(2-broMo-5-fluorobenzyl)-6-chloro-3-MethylpriMidine-2,4(1H, 3H)-dione
2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile
(R)-2-[[6-(3-AMinopiperidin-1-yl)-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl]Methyl]-4-fluorobenzonitrile
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-
(R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile(Trelagliptin)
Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile
TrelagliptinQ: What is Trelagliptin Q: What is the CAS Number of Trelagliptin Q: What is the storage condition of Trelagliptin Q: What are the applications of Trelagliptin
[EINECS(EC#)]

1592732-453-0
[Molecular Formula]

C18H20FN5O2
[MDL Number]

MFCD22572746
[MOL File]

865759-25-7.mol
[Molecular Weight]

357.382
Chemical PropertiesBack Directory
[Boiling point ]

519.0±60.0 °C(Predicted)
[density ]

1.38±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
[form ]

solid
[pka]

9.88±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

Trelagliptin is a highly selective, long-acting dipeptidyl peptidase IV (DPP-4) inhibitor. This inhibitor provides sustained reduction of plasma DPP-4 activity and lowering of blood glucose in animal models of diabetes.
[Definition]

ChEBI: Trelagliptin is a member of benzenes and a nitrile.
[Biological Activity]

trelagliptin (syr-472) is a selective inhibitor of dpp-4 and is developed for the treatment of type 2 diabetes mellitus (t2dm) [1].dipeptidyl peptidase (dpp)-4 also known as adenosine deaminase complexing protein 2 or cd26 is an antigenic enzyme that expressed on the surface of most cell types and plays an important role in regulating immune system, signal transduction and apoptosis [2, 3].trelagliptin (syr-472) is a potent dpp-4 inhibitor and can be administered once weekly which unlike its other class approved agents that be taken once daily [1]. in japan,
[target]

DPP-4
[References]

[1]. mckeage, k., trelagliptin: first global approval. drugs, 2015. 75(10): p. 1161-4.
[2]. inagaki, n., et al., once-weekly trelagliptin versus daily alogliptin in japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study. lancet diabetes endocrinol, 2015. 3(3): p. 191-7.
[3]. inagaki, n., et al., syr-472, a novel once-weekly dipeptidyl peptidase-4 (dpp-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. lancet diabetes endocrinol, 2014. 2(2): p. 125-32.
Spectrum DetailBack Directory
[Spectrum Detail]

Trelagliptin(865759-25-7)1HNMR
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