| Identification | Back Directory | [Name]
URB754 | [CAS]
86672-58-4 | [Synonyms]
URB754
URB754, >=98%
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one
6-Methyl-2-(p-tolylMino)-4H-benzo[d][1,3]oxazin-4-one
6-Methyl-2-(p-tolylaMino)-4H-benzo[d][1,3]oxazin-4-one
6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
6-Methyl-2-(p-tolylaMino)-1H-benzo[d][1,3]oxazin-4(2H)-one
6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one
6-Methyl-2-(p-tolylamino)-4H-3,1-benzoxazin-4-one | [Molecular Formula]
C16H14N2O2 | [MDL Number]
MFCD03272508 | [MOL File]
86672-58-4.mol | [Molecular Weight]
266.29 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
238-240°C | [Boiling point ]
434.0±48.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Off-white solid. | [pka]
3.76±0.20(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 and binds weakly to the rat CB1 r | [Uses]
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management. | [Description]
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management. | [References]
[1] JUDIT K MAKARA. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus[J]. Nature neuroscience, 2005, 8 9: 1139-1141. DOI: 10.1038/nn1521
[2] SUSANNA M SAARIO. URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain.[J]. Chemistry & biology, 2006, 13 8: 811-814. DOI: 10.1016/j.chembiol.2006.07.008
[3] S VANDEVOORDE. Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro[J]. British Journal of Pharmacology, 2009, 150 2: 186-191. DOI: 10.1038/sj.bjp.0706971
[4] GIORGIO TARZIA. Identification of a Bioactive Impurity in a Commercial Sample of 6-Methyl-2-p-Tolylaminobenzo[d][1,3]Oxazin-4-One (URB754)[J]. Annali di chimica, 2007, 97 9: 887-894. DOI: 10.1002/adic.200790073
[5] ANDREA G. HOHMANN. An endocannabinoid mechanism for stress-induced analgesia[J]. Nature, 2005, 435 7045: 1108-1112. DOI: 10.1038/nature03658 |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Telephone: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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