| Identification | Back Directory | [Name]
halenaquinone | [CAS]
86690-14-4 | [Synonyms]
halenaquinone
(S)-12bβ-Methyl-1H-5-oxabenzo[k]acephenanthrylene-3,6,8,11(2H,12bH)-tetrone
1H-Benzo[6,7]phenanthro[10,1-bc]furan-3,6,8,11(2H,12bH)-tetrone, 12b-methyl-, (12bS)- | [Molecular Formula]
C20H12O5 | [MOL File]
86690-14-4.mol | [Molecular Weight]
332.31 |
| Hazard Information | Back Directory | [Uses]
Halenaquinone is a phosphatidylinositol 3-kinase inhibitor and can be isolated from the marine sponge Petrosia alfiani. Halenaquinone inhibits RANKL-induced osteoclastogenesis, and induces cell apoptosis in PC12 cells[1][2][3]. | [References]
[1] Deborah M. Roll, et al. Halenaquinone, a pentacyclic polyketide from a marine sponge. ：Journal of the American Chemical Society.Vol 105/Issue 19.
[2] Tsukamoto S, et al. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Bioorg Med Chem Lett. 2014;24(22):5315-5317. DOI:10.1016/j.bmcl.2014.09.043
[3] Fujiwara H, et al. Halenaquinone, a novel phosphatidylinositol 3-kinase inhibitor from a marine sponge, induces apoptosis in PC12 cells. Eur J Pharmacol. 2001;413(1):37-45. DOI:10.1016/s0014-2999(00)00944-4 |
|
|