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867330-68-5

867330-68-5 Structure

867330-68-5 Structure
IdentificationBack Directory
[Name]

1,2,4-Benzotriazin-3-aMine, 7-(2,6-dichlorophenyl)-5-Methyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
[CAS]

867330-68-5
[Synonyms]

1,2,4-Benzotriazin-3-aMine, 7-(2,6-dichlorophenyl)-5-Methyl-N-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-
[Molecular Formula]

C26H25Cl2N5O
[MDL Number]

MFCD24038922
[MOL File]

867330-68-5.mol
[Molecular Weight]

494.42
Chemical PropertiesBack Directory
[Boiling point ]

642.3±65.0 °C(Predicted)
[density ]

1.332±0.06 g/cm3(Predicted)
[pka]

9.59±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

TG-100435 is a multitargeted, orally active protein tyrosine kinase inhibitor, with Ki of 13 to 64 nM for Src, Lyn, Abl, Yes, Lck, and EphB4. TG-100435 plays an important role in cancer research[1].
[References]

[1] Steven X Hu, et al. Metabolism and pharmacokinetics of a novel Src kinase inhibitor TG100435 ([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine) and its active N-oxide metabolite TG100855 ([7-(2,6-dichloro-phenyl)-5-methylbenzo[1,2,4]triazin-3-yl]-{4-[2-(1-oxy-pyrrolidin-1-yl)-ethoxy]-phenyl}-amine). Comparative Study Drug Metab Dispos. 2007 Jun;35(6):929-36. DOI:10.1124/dmd.106.014290
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