| Identification | Back Directory | [Name]
(11,12-DiHETE | [CAS]
867350-92-3 | [Synonyms]
(11,12-DiHETE
11,12-dihydroxy-5(Z),8(Z),14(Z),17(Z)-eicosatetraenoic acid
11,12-dihydroxy-5(Z),8(Z),14(Z),17(Z)-Eicosapentaenoic acid | [Molecular Formula]
C20H32O4 | [MOL File]
867350-92-3.mol | [Molecular Weight]
336.47 |
| Chemical Properties | Back Directory | [Boiling point ]
515.8±50.0 °C(Predicted) | [density ]
1.040±0.06 g/cm3(Predicted) | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml | [pka]
4.75±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
(±)11(12)-DiHETE is a dihydroxy metabolite of EPA produced by cytochrome P450-mediated epoxide formation and subsequent hydrolysis by epoxide hydrolase. Plasma levels of (±)11(12)-DiHETE are increased over baseline after an oral dose of 1008 mg EPA.1 | [Uses]
11,12-DiHETE is an orally active metabolite produced by cytochrome p450 mediated epoxide formation and subsequent epoxide hydrolase production[1]. | [Definition]
ChEBI: 11,12-DiHETE is a polyunsaturated fatty acid and a hydroxy fatty acid. | [References]
1. Schuchardt, J.P., Schneider, I., Willenberg, I., et al. Increase of EPA-derived hydroxy, epoxy and dihydroxy fatty acid levels in human plasma after a single dose of long-chain omega-3 PUFA Prostaglandins Other Lipid Mediat. 109-111,23-31(2014). |
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