| Chemical Properties | Back Directory | [Boiling point ]
1302.9±65.0 °C(Predicted) | [density ]
1.091±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 1 mg/ml in 0.25% acetic acid | [form ]
Powder | [pka]
3.27±0.10(Predicted) | [color ]
White | [Sequence]
{(2R)-2,3-Bis(1-oxohexadecyl)oxy]propyl}-Cys-Ser-Lys-Lys-Lys-Lys |
| Hazard Information | Back Directory | [Uses]
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages[1][2][3]. | [storage]
Store at -20°C | [References]
[1] Parra-Izquierdo I, et al. The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton's Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions. Front Immunol. 2021 Aug 30;12:729951. DOI:10.3389/fimmu.2021.729951
[2] Kulsantiwong P, et al. Pam2CSK4 and Pam3CSK4 induce iNOS expression via TBK1 and MyD88 molecules in mouse macrophage cell line RAW264.7. Inflamm Res. 2017 Oct;66(10):843-853. DOI:10.1007/s00011-017-1063-1
[3] Kaur A, et al. An efficient and scalable synthesis of potent TLR2 agonistic PAM2CSK4. RSC Adv. 2018 Mar 5;8(18):9587-9596. DOI:10.1039/c8ra01387j |
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