| Identification | Back Directory | [Name]
Benzyl-PEG7-amino | [CAS]
868594-43-8 | [Synonyms]
CAS_868594-43-8
Benzyl-PEG7-NH2
Benzyl-PEG7-amino
Benzyl-PEG6-amino
Benzyl-PEG6-amine
Benzyl-PEG7-amine
H2N-(CH2CH2O)7-Bn
BnO-PEG6-CH2CH2NH2
3,6,9,12,15,18,21-Heptaoxadocosan-1-amine, 22-phenyl-
20-(phenylmethyloxy)-3,6,9,12,15,18-hexaoxaeicosylamine | [Molecular Formula]
C21H37NO7 | [MOL File]
868594-43-8.mol | [Molecular Weight]
415.52 |
| Hazard Information | Back Directory | [Biological Activity]
Benzyl-PEG7-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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