Identification | Back Directory | [Name]
1-Piperazineacetamide, N-[5-(aminocarbonyl)tricyclo[3.3.1.13,7]dec-2-yl]-α,α-dimethyl-4-[5-(trifluoromethyl)-2-pyridinyl]-, stereoisomer | [CAS]
868623-40-9 | [Synonyms]
ABT-384 1-Piperazineacetamide, N-[5-(aminocarbonyl)tricyclo[3.3.1.13,7]dec-2-yl]-α,α-dimethyl-4-[5-(trifluoromethyl)-2-pyridinyl]-, stereoisomer | [Molecular Formula]
C25H34F3N5O2 | [MOL File]
868623-40-9.mol | [Molecular Weight]
493.57 |
Chemical Properties | Back Directory | [Boiling point ]
689.3±55.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | [form ]
Solid | [pka]
16.76±0.40(Predicted) | [color ]
White to off-white |
Hazard Information | Back Directory | [Uses]
ABT-384 is a potent, selective 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor. ABT-384 exhibits high affinity (Ki 0.1-2.7 nM) against rodent, monkey, and human 11β-HSD1. ABT-384 blocks regeneration of active cortisol. ABT-384 can be used for the research of Alzheimer’s disease (AD)[1][2]. | [storage]
4°C, protect from light | [References]
[1] Katz DA, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3(8):e295. Published 2013 Aug 27. DOI:10.1038/tp.2013.67 [2] Liu W, et al. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults. Clin Pharmacol Drug Dev. 2013;2(2):133-151. DOI:10.1002/cpdd.5 |
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