| Identification | Back Directory | [Name]
3-hydroxypyridine-4-carbonitrile | [CAS]
87032-82-4 | [Synonyms]
4-Cyano-3-hydroxypyridine
3-Hydroxyisonicotinonitrile
3-hydroxy-4-Pyridinecarbonitrile
3-hydroxypyridine-4-carbonitrile
4-Pyridinecarbonitrile, 3-hydroxy-
6- (tert butyl aminomethyl) isonicotinic acid
3-Hydroxypyridine-4-carbonitrile, 4-Cyano-3-hydroxypyridine | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C6H4N2O | [MOL File]
87032-82-4.mol | [Molecular Weight]
120.11 |
| Chemical Properties | Back Directory | [Melting point ]
166 °C | [Boiling point ]
393.6±27.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
5.38±0.10(Predicted) | [Appearance]
Off-white to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
Step C: Preparation of 3-hydroxyisonicotinonitrile: 3-(2-(trimethylmethylsilyl)ethoxy)isonicotinonitrile (1.30 g, 5.90 mmol) and anhydrous THF (5 mL) were added to a dry reaction flask, followed by slow addition of ammonium fluoride (11.8 mL, 11.8 mmol) to the THF solution. The reaction mixture was stirred at room temperature for 1 h, after which the solvent was removed by concentration via rotary evaporator. The crude product was purified by silica gel column chromatography using sequentially dichloromethane and dichloromethane solution containing 5% methanol as eluents to afford the target product 3-hydroxyisonicotinonitrile (0.7 g, 99% yield) as a dark brown oil. | [References]
[1] Patent: WO2008/91770, 2008, A1. Location in patent: Page/Page column 32
[2] Patent: WO2007/89512, 2007, A1. Location in patent: Page/Page column 194 |
|
|