| Identification | Back Directory | [Name]
N-Methyl-2-aminopyridine-3-carboxamide | [CAS]
870997-87-8 | [Synonyms]
N-Methyl-2-aminonicotinamide
2-Amino-N-methylnicotinamide
N-methyl-2-amino-3-nicotinamide
N-Methyl-2-aminopyridine-3-carboxamide
2-amino-N-methylpyridine-3-carboxamide
3-Pyridinecarboxamide,2-amino-N-methyl-
N-Methyl-2-aminopyridine-3-carboxamide ISO 9001：2015 REACH | [Molecular Formula]
C7H9N3O | [MOL File]
870997-87-8.mol | [Molecular Weight]
151.17 |
| Chemical Properties | Back Directory | [Melting point ]
149 - 151°C | [Boiling point ]
373.1±27.0 °C(Predicted) | [density ]
1.206 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
Solid | [pka]
14.44±0.46(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
2-Amino-N-methylpyridine-3-carboxamide is used in preparation of triazolopyrazine derivatives and analogs for use as c-MET kinase activity inhibitors. | [Synthesis]
To 2-aminonicotinic acid (2.0 g, 14.5 mmol) and methylamine hydrochloride (1.47 g, 1.5 eq.) were added EDC (4.49 g, 1.5 eq.), HOBt (2.35 g, 1.2 eq.), and DIEA (7.6 mL, 3.0 eq.) sequentially in DMF (20 mL). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the crude product was concentrated and the residue was dissolved in EtOAc. The organic phase was washed with saturated NaHCO3 solution. After removing the solvent under reduced pressure, the crude product was purified by silica gel column chromatography (eluent: 0%-20% MeOH/DCM) to afford the target compound 2-amino-N-methylnicotinamide (2.16 g, isolated yield 98%). | [References]
[1] Patent: WO2008/115369, 2008, A2. Location in patent: Page/Page column 130 |
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