| Identification | Back Directory | [Name]
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE | [CAS]
871022-62-7 | [Synonyms]
4-(Boc-aMinoMethyl)-4-fluoropiperidine
TERT-BUTYL (4-FLUOROPIPERIDIN-4-YL)METHYLCARBAMATE
tert-butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
tert-butyl N-(4-fluoro-4-piperidyl)-N-methyl-carbamate
tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate
4-[(tert-Butoxycarbonylamino)methyl]-4-fluoropiperidine
tert-butyl (4-Fluoropiperidin-4-yl)methylcarbamate hydrochloride
[(4-Fluoro-4-piperidinyl)methyl]carbamic acid 1,1-dimethylethyl ester
Carbamic acid, [(4-fluoro-4-piperidinyl)methyl]-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C11H21FN2O2 | [MDL Number]
MFCD11973738 | [MOL File]
871022-62-7.mol | [Molecular Weight]
232.29 |
| Chemical Properties | Back Directory | [Boiling point ]
324.8±27.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C, protect from light | [pka]
12.72±0.46(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
tert-?Butyl (4-?Fluoro-?4-?piperidinyl)?methylcarbamate is a reagent used in the preparation of cyanophenylglycine derivatives which may act as reversible inhibitors of lysine demethylase 1 which is involved in the differentiation of leukemia stem cells in ACM. | [Synthesis]
N-benzoyl-4-tert-butoxycarbonylaminomethyl-4-fluoropiperidine (the product of Step 3 of Example 15, 4.42 g, 13.1 mmol) was used as a raw material and reacted with NaOH (2.62 g, 65.5 mmol) at reflux in a mixed solvent of H2O (9.00 mL) and ethanol (90.0 mL) for 15 hours. After completion of the reaction, the mixture was concentrated in vacuum. Water and chloroform were added to the concentrated residue and the organic layer was separated. The organic layer was dried with magnesium sulfate and concentrated under reduced pressure to remove the solvent. The resulting solid was recrystallized by hexane-CH2Cl2 mixed solvent to give 1.77 g (58% yield) of the target product ((4-fluoropiperidin-4-yl)methyl)carbamic acid tert-butyl ester as a colorless solid. Mass spectrum (ESI) m/z: 233 (M + H)+. 1H NMR (CDCl3) δ 4.93 (1H, m), 3.30 (2H, dd, J = 21.5,6.3Hz), 2.91 (4H, m), 1.88-1.34 (4H, m), 1.45 (9H, s). No signal corresponding to the amino group was observed. | [References]
[1] Patent: US2005/277671, 2005, A1. Location in patent: Page/Page column 38
[2] Patent: US2006/194842, 2006, A1. Location in patent: Page/Page column 37 |
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