| Identification | Back Directory | [Name]
tert-butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate | [CAS]
871726-73-7 | [Synonyms]
6-BOC-2,4,5,7-Tetrahydro-pyrazolo[3,4-c]pyridine
6-Boc-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine
6-Boc-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine
tert-Butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)
tert-butyl 1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-6-carboxylate
tert-Butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxyl
t-Butyl 4,5-Dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
tert-butyl 1,4,5,7-tetrahydropyrazolo[3,4-c]pyridine-6-carboxylate
tert-butyl 4,5-dihydro-2H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
tert-butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate
tert-Butyl1,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylate
2,4,5,7-Tetrahydro-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl este
1,4,5,7-Tetrahydro-6H-pyrazolo[3,4-c]pyridine-6-carboxylic acid tert-butyl ester
tert-Butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate-6(7H)-carboxylate
6H-Pyrazolo[3,4-c]pyridine-6-carboxylic acid, 1,4,5,7-tetrahydro-,1,1-dimethylethyl ester | [Molecular Formula]
C11H17N3O2 | [MDL Number]
MFCD11044813 | [MOL File]
871726-73-7.mol | [Molecular Weight]
223.27 |
| Chemical Properties | Back Directory | [Boiling point ]
388.0±42.0 °C(Predicted) | [density ]
1.200 | [storage temp. ]
Sealed in dry,2-8°C | [pka]
14.93±0.20(Predicted) | [Appearance]
White to light yellow Solid | [InChI]
InChI=1S/C11H17N3O2/c1-11(2,3)16-10(15)14-5-4-8-6-12-13-9(8)7-14/h6H,4-5,7H2,1-3H3,(H,12,13) | [InChIKey]
XSHYMCSSTAWZOW-UHFFFAOYSA-N | [SMILES]
C1N(C(OC(C)(C)C)=O)CCC2C=NNC1=2 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl 4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-6(7H)-carboxylate from tert-butyl 4-((dimethylamino)methylene)-3-oxopiperidine-1-carboxylate: to a stirred tert-butyl 4-((dimethylamino)methylene)-3-oxopiperidine-1-carboxylate (1.0 g, 4 mmol) ethanol (EtOH. 10 mL) solution was added to hydrazine hydrate (376 mg, 10 mmol). The reaction mixture was stirred at 80 °C for 16 h until liquid chromatography-mass spectrometry (LCMS) analysis showed that the reaction was complete. After completion of the reaction, the mixture was concentrated and the residue was diluted with water (30 mL) and extracted with ethyl acetate (EA, 3 x 30 mL). The organic phases were combined, washed with brine (20 mL), dried over anhydrous sodium sulfate (Na2SO4) and concentrated. The resulting residue was used directly in the next step of the reaction (810 mg, 90% yield).LCMS data: 224.1 (M + 1), 114.1 (M + 1-100), 168.1 (M + 1-56). | [References]
[1] Patent: WO2014/100695, 2014, A1. Location in patent: Paragraph 00413 |
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