| Identification | Back Directory | [Name]
2H-1,2,3-Triazole-4-carboxamide, N-[2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl]-N-methyl-2-phenyl- | [CAS]
872113-12-7 | [Synonyms]
TCMDC-125457
2H-1,2,3-Triazole-4-carboxamide, N-[2-[(5-chloro-2-methoxyphenyl)amino]-2-oxoethyl]-N-methyl-2-phenyl- | [Molecular Formula]
C19H18ClN5O3 | [MOL File]
872113-12-7.mol | [Molecular Weight]
399.83 |
| Hazard Information | Back Directory | [Uses]
TCMDC-125457 is potent in inducing calcium redistribution but minimally inhibits heme crystallization. TCMDC-125457 demonstrated high efficacy when pulsed in a single-dose combination with artesunate against tightly synchronized artemisinin-resistant ring-stage parasites. | [References]
[1] Chia W, et al. High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372. DOI:10.1021/acschembio.1c00512 |
|
|