| Identification | Back Directory | [Name]
1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione | [CAS]
872254-32-5 | [Synonyms]
Caspase-3-IN-1
1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
1H-Indole-2,3-dione, 1-[(4-methoxyphenyl)methyl]-5-[[(2S)-2-[(3-pyridinyloxy)methyl]-1-pyrrolidinyl]sulfonyl]- | [Molecular Formula]
C26H25N3O6S | [MDL Number]
MFCD09265256 | [MOL File]
872254-32-5.mol | [Molecular Weight]
507.56 |
| Chemical Properties | Back Directory | [Melting point ]
156.7-158.4 °C(Solv: ethyl ether (60-29-7)) | [Boiling point ]
732.1±70.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: >10mg/mL | [form ]
solid | [pka]
4.67±0.10(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) T cells from pleural effusions, mononuclear cells (PEMCs). | [Biological Activity]
1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor. | [IC 50]
Caspase-3: 14.5?±?1.6 nM (IC50); Caspase-7: 21.8?±?3.5 nM (IC50); Caspase-6: >5000 nM (IC50); Caspase-1: >10000 nM (IC50); Caspase-8: >50000 nM (IC50) |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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