| Identification | Back Directory | [Name]
6H-1,2,3-Triazolo[4,5-d]pyrimidine-6-acetamide, N-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethylphenyl)-3,7-dihydro-7-oxo- | [CAS]
872591-16-7 | [Synonyms]
ERK2 allosteric-IN-1 6H-1,2,3-Triazolo[4,5-d]pyrimidine-6-acetamide, N-(1,3-benzodioxol-5-ylmethyl)-3-(3,4-dimethylphenyl)-3,7-dihydro-7-oxo- | [Molecular Formula]
C22 H20 N6 O4 | [MOL File]
872591-16-7.mol | [Molecular Weight]
432.43 |
| Hazard Information | Back Directory | [Uses]
ERK2 allosteric-IN-1 (compound 1) is a selective and allosteric ERK2 inhibitor with the IC50 of 11 μM[1]. | [IC 50]
ERK2: 11 μM (IC50) | [References]
[1] Sugiyama H, et al. Low entropic cost of binding confers high selectivity on an allosteric ERK2 inhibitor. Bioorg Med Chem Lett. 2023;93:129431. DOI:10.1016/j.bmcl.2023.129431 |
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