| Identification | Back Directory | [Name]
MTX3 | [CAS]
873336-87-9 | [Synonyms]
MT-3
MTX3
MUSCARINIC TOXIN-3
MT-3, DENDROASPIS ANGUSTICEPS
Muscarinic Toxin-3 from Dendroaspis angusticeps venom | [MDL Number]
MFCD00286053 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [Sequence]
Leu-Thr-Cys-Val-Thr-Lys-Asn-Thr-Ile-Phe-Gly-Ile-Thr-Thr-Glu-Asn-Cys-Pro-Ala-Gly-Gln-Asn-Leu-Cys-Phe-Lys-Arg-Trp-His-Tyr-Val-Ile-Pro-Arg-Tyr-Thr-Glu-Ile-Thr-Arg-Gly-Cys-Ala-Ala-Thr-Cys-Pro-Ile-Pro-Glu-Asn-Tyr-Asp-Ser-Ile-His-Cys-Cys-Lys-Thr-Asp-Lys-Cys-Asn-Glu (Disulfide bridge: Cys3-Cys24,Cys17-Cys42,Cys46-Cys57,Cys58-Cys63) |
| Hazard Information | Back Directory | [Uses]
Muscarinic toxin 3 (MT3) is a potent and non-competitive mAChR and adrenoceptors antagonist with pIC50s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M1, M4, α1A, α1B, α1D,α2A,α2B and α2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity[1]. | [References]
[1] N?reoja K, et al. Adrenoceptor activity of muscarinic toxins identified from mamba venoms. Br J Pharmacol. 2011 Sep;164(2b):538-50. DOI:10.1111/j.1476-5381.2011.01468.x |
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