874208-84-1

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874208-84-1 Structure

Identification	Back Directory
[Molecular Weight] 250.29

Chemical Properties	Back Directory
[Boiling point ] 366.2±32.0 °C(Predicted)
[density ] 1.087±0.06 g/cm3(Predicted)
[form ] Liquid
[pka] 4.63±0.10(Predicted)
[color ] Colorless to light yellow

Hazard Information	Back Directory
[Description] m-PEG4-(CH2)3-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses] m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
[IC 50] PEGs
[References] [1] Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9. DOI:10.1021/mp2005774

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