ChemicalBook--->CAS DataBase List--->874208-84-1

874208-84-1

874208-84-1 Structure

874208-84-1 Structure
IdentificationBack Directory
[Molecular Weight]

250.29
Chemical PropertiesBack Directory
[Boiling point ]

366.2±32.0 °C(Predicted)
[density ]

1.087±0.06 g/cm3(Predicted)
[storage temp. ]

Storage temp. 2-8°C
[form ]

Liquid
[pka]

4.63±0.10(Predicted)
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

m-PEG4-(CH2)3-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.
[Uses]

m-PEG4-CH2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] Zuluaga MF, et al. Enhanced prostate cancer targeting by modified protease sensitive photosensitizer prodrugs. Mol Pharm. 2012 Jun 4;9(6):1570-9. DOI:10.1021/mp2005774
Spectrum DetailBack Directory
[Spectrum Detail]

m-PEG4-(CH2)3-acid(874208-84-1)1HNMR
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