| Identification | Back Directory | [Name]
3H-Pyrrol-3-one, 4-acetyl-1,2-dihydro-5-hydroxy-2-(2-methylpropyl)-, (2R)- | [CAS]
875455-92-8 | [Synonyms]
(R)-4-Acetyl-5-hydroxy-2-isobutyl-1,2-dihydro-3H-pyrrol-3-one
3H-Pyrrol-3-one, 4-acetyl-1,2-dihydro-5-hydroxy-2-(2-methylpropyl)-, (2R)- | [Molecular Formula]
C10H15NO3 | [MOL File]
875455-92-8.mol | [Molecular Weight]
197.23 |
| Chemical Properties | Back Directory | [Melting point ]
133-134 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
327.4±42.0 °C(Predicted) | [density ]
1.162±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.50±1.00(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse[1]. | [in vivo]
Mutanocyclin (32 μg/mL; 24 h infects tongues of mouse) inhibits yeast-form in ex vivo mouse tongue infection models of C. albicans[1].
Mutanocyclin (6.4, 12.8, 25.6 μg/mL; 48 h) attenuates the virulence of C. albicans in the G. mellonellainfection model[1]. | [References]
[1] Tao L, et al. Streptococcus mutans suppresses filamentous growth of Candida albicans through secreting mutanocyclin, an unacylated tetramic acid. Virulence. 2022 Dec;13(1):542-557. DOI:10.1080/21505594.2022.2046952 |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
TargetMol
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| Telephone: |
400-821-0310 15002144251 |
| Website: |
www.targetmol.cn/ |
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