| Identification | Back Directory | [Name]
Revefenacin | [CAS]
876296-47-8 | [Synonyms]
Glycinamide, L-cysteinyl-L-phenylalanyl-L-isoleucyl-6-oxo-L-lysyl-L-asparaginyl-L-cysteinyl-L-prolyl-N5-(1-methylethyl)-L-ornithyl-, cyclic (1→6)-disulfide | [Molecular Formula]
C46H73N13O11S2 | [MOL File]
876296-47-8.mol | [Molecular Weight]
1048.28 |
| Chemical Properties | Back Directory | [Boiling point ]
1512.1±65.0 °C(Predicted) | [density ]
1.229±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.82±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4]. | [in vivo]
Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[3].
| Animal Model: | LPS-induced, fluid-resuscitated rabbit endotoxemia model[2]. | | Dosage: | 1 μg/kg/min | | Administration: | Left jugular vein infusion for 12 min | | Result: | Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits. |
| [References]
[1] Russell JA, et al. Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients. Crit Care. 2017 Aug 15;21(1):213. DOI:10.1186/s13054-017-1798-7
[2] Milano SP, et al. Selepressin, a novel selective V1A receptor agonist: Effect on mesenteric flow and gastric mucosa perfusion in the endotoxemic rabbit. Peptides. 2020 Jul;129:170318. DOI:10.1016/j.peptides.2020.170318
[3] Barabutis N, et al. Protective Mechanism of the Selective Vasopressin V1A Receptor Agonist Selepressin against Endothelial Barrier Dysfunction. J Pharmacol Exp Ther. 2020 Nov;375(2):286-295. DOI:10.1124/jpet.120.000146
[4] Maybauer MO, et al. The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis*. Crit Care Med. 2014 Jul;42(7):e525-e533. DOI:10.1097/CCM.0000000000000300 |
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