| Chemical Properties | Back Directory | [Boiling point ]
467.517±45.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.468±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
2.298±0.20(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells[1]. | [References]
[1] He S, et al. Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J Med Chem. 2023 Jul 6. DOI:10.1021/acs.jmedchem.3c00213 |
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